Thursday, September 22, 2016

Chemotherapy Treatment options for Uterine Sarcomas


List of current chemotherapy options for Uterine Sarcoma from Cancer Therapy Advisor

Decarbazine - From UK Cancer research.org  - Alkylating agent that sticks to and damages cancer DNA cells preventing them from dividing. - 800 - 1000 mg/m2 every three weeks.

Doxorubicin - From UK Cancer research.org - An anthracycline drug that blocks an enzyme call topo isomerase 2 that cancer cells use to grow and reproduce. 

Trabectedin - From UK Cancer research.org - A chemotherapy agent that sticks to and damages cancer DNA cells preventing them from dividing. - 24 hour drip once every 3 weeks

Immunotherapy options.  From cancer research.org

A phase II trial of pembrolizumab (Keytruda®), an anti-PD-1 antibody, plus axitinib, which inhibits VEGF and PDGF, which help the tumors get nutrients (called angiogenesis), in patients with advanced alveolar soft part sarcoma and other soft tissue sarcoma (NCT02636725). There is also a phase II trial of pembrolizumab in patients with advanced non-resectable or metastatic sarcoma (NCT02406781), a phase I/II trial of pembrolizumab plus chemotherapy in patients with advanced cancer, including sarcoma (NCT02331251), and a phase I trial of pembrolizumab in patients with HIV and relapsed, refractory, or disseminated cancer, including Kaposi sarcoma (NCT02595866). - See more at: http://www.cancerresearch.org/cancer-immunotherapy/impacting-all-cancers/sarcoma#sthash.2ZQ8MmVx.dpuf









http://www.cancerresearchuk.org/about-cancer/cancers-in-general/treatment/cancer-drugs/dacarbazine

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